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Sildenafil 50 mg for pulmonary hypertension, and sildenafil 10 mg for treatment of erectile dysfunction. F. Other Drugs That Can Increase Your Basal Serotonin Levels In addition to the drugs mentioned above, other may increase your body's ability to produce serotonin on its own. Drugs that produce serotonin or interfere with the normal synthesis of serotonin include the antidepressant selective reuptake inhibitors (SSRI's) and the tricyclic antidepressants, such as desipramine and some combination of the tricyclics. tricyclics increase blood levels of serotonin, and when combined with other medications or alcohol, they may increase the drug dose required to elevate your body's serotonin levels. In addition, some SSRI's and TCAs, including fluoxetine the newer serotonin norepinephrine reuptake inhibitors (SNRIs), also cause your body to produce the natural chemical messenger, norepinephrine, which will, in turn, decrease serotonin levels (Dowling et al, 2005). In general, SSRIs increase the amount of serotonin in brain by increasing reuptake or inhibition. This reduces the amount of serotonin that enters the brain and makes patient feel "high". Tricyclic antidepressants increase the amount of serotonin by releasing out the receptors in brain, also known as releasing serotonin. These antidepressants must be taken at the same time as a drug that raises the level of serotonin in brain, because the body may not be able to produce adequate amounts of serotonin on its own. Thus the effect of taking a TCAs and an SSRI is to raise the serum level of both drugs, but the effect of this combination, in particular the effects on sexual function, may be more pronounced. In studies, most subjects reported improvements in sexual arousal and satisfaction with the combination of fluoxetine and fluvoxamine, with the combination producing greatest improvement. Some patients take a combination of the two SSRIs (fluoxetine and citalopram) to enhance their sexual experience while on antidepressants. The combination has potential to improve mood, appetite, sexual sensitivity, body temperature, and other symptoms related to the antidepressant (Dowling and Niesink, 1997). The combination was originally created because of the combination's superior action both SSRIs and citalopram, but results have varied widely, from only a modest increase to significant increase. If an increase in sexual functioning is observed, these patients report that it is more likely due to an improvement in side effects on both antidepressants. In general, it appears that for most patients the increase in order sildenafil online sexual activity produced by the combination of drugs is very minor. In addition to the SSRIs and TCAs, a large number of drugs that increase the activity of serotonin also increase your body's production of serotonin. However, it is well established that the brain's production of serotonin.

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